Assalamu'alaikum semua!!!
Kali ini aku mau bagiin review journal nihhh..
Selamat membaca yaaaa
Abstract
The
mechanism of bone resorption and remodeling is coordinated by the interaction
among the receptor activator of nuclear factor-kappa B (RANK), RANK ligand
(RANKL), and its decoy soluble receptor osteoprotegerin (OPG). RANKL is a
homotrimeric transmembrane protein that is expressed as a membrane bound and a
secreted protein which is derived from the membrane form as a result of either
proteolitic cleavage or alternative splicing. Many cell types express RANKL,
including osteoblasts, periodontal ligament fibroblasts, and endothelial cells.
In molecular mechanism of RANKL, RANKL production from fibroblast stimulated by
periodontal pathogens, bacterial antigen specific T and B lymphocyte are key
players, and there is co-stimulatory molecules. The primary aim of this paper
is to explain RANKL-mediated osteoclastogenesis.
Key
words : RANKL, interaction of RANK-RANKL-OPG, RANKL-mediated
osteoclastogenesis, immune cells
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